For over 40 years, Cerbios has been a worldwide market leader for the manufacture and supply of reduced Folates. 

Folates are a class of water soluble compounds belonging to the Vitamin B complex which are essential for a number of metabolic functions, including processes involved in the development and metabolism of CNS and the production of DNA and RNA, primarily in infancy, adolescence and pregnancy.

Calcium Levomefolate is the active metabolic form of folates in the body.

Folate deficiency consequences can be as serious as birth defects (i.e. “spina bifida”), megaloblastic anaemia, and some types of depression.

Calcium Levomefolate can be the most effective treatment to remedy those deficiencies.


Calcium Levomefolate is formulated in many medical supplements for cases of folate deficiency or need for increased uptake; it is prescribed during pregnancy to prevent birth defects associated with CNS formation and functionality.

It is also the active ingredient in medicinal products prescribed for certain types of depression, disturbed behaviour and Mild Cognitive Impairment (MCI)


CAS Number :
Formula :
Molecular Weight :

497.5 g/mol


EU :

DCP or MR or EFSA 


  • Reduced folates

Therapeutic area

  • Vitamin and antianaemic preparations
  • Women’s health
  • Coadjuvant for hormonal contraceptive
  • Dermatology


  • (6S)-N5-Methyl-5,6,7,8-tetrahydrofolic acid Calcium Salt
  • L-5-methyltetrahydrofolic acid, calcium salt
  • Calcium L-mefolinate
  • L-methylfolate
  • (6S)-methyltetrahydrofolic acid, calcium salt