Cerbios supplies different HPAPI derivatives of Vitamin D worldwide.

Cerbios has been manufacturing and commercialising HPAPI derivatives of Vitamin D3 since 1993 and is continuously working to develop new products and improve their quality.

Doxercalciferol is a synthetic Vitamin D2 analogue undergoing metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of Vitamin D2.

It regulates blood calcium at levels required for essential body functions, acting on bone cells (osteoblasts) to stimulate skeletal growth and on the parathyroid glands to suppress PTH synthesis and secretion.

USE

Doxercalciferol is used  in secondary hyperparathyroidism in adult patients  with chronic kidney disease (CKD) and adult patients with CKD on dialysis.

PROPERTIES

CAS Number :
Formula :
Molecular Weight :

54573-75-0
C28H44O2
412.6 g/mol

REGULATORY

FDA :
China DFM :

028353
Y20180000820 (*)

*Application ongoing

Family

  • Vitamin D derivatives

Therapeutic area

  • Anti-parathyroid agents
  • Hyperparathyroidism

Synonims

  • (1S,3S,5E,7E,17α,22E,24S)-9,10-Secoergosta-5,7,10,22-tetraene-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
  • 1-α-hydroxyvitamin D2,
  • 1α-hydroxyergocalciferol