For over 40 years, Cerbios has been a worldwide market leader for the manufacture and supply of reduced Folates. 

Folates are a class of water soluble compounds belonging to the Vitamin B complex which are essential for a number of metabolic functions, including processes involved in the development and metabolism of CNS and the production of DNA and RNA, primarily in infancy, adolescence and pregnancy.

Reduced folates are manufactured at Cerbios, inspected and supplied at the highest quality standards in accordance with all regulatory requirements.

Calcium Folinate Hydrate/Leucovorin Calcium is a reduced derivative of Folic Acid which is widely used in various therapies.

USE

Calcium Folinate is mainly used for colorectal cancer treatment in association with 5-fluorouracil and Oxaliplatin (FOLFOX egimen) or with 5-fluorouracil and Irinotecan (FOLFIRI regimen).

Additionally, it is administered as salvage therapy to reduce toxic effects after high doses of methotrexate in the treatment of some neoplastic diseases, rheumatoid arthritis or severe psoriasis.

Calcium Folinate is also given to treat anaemia caused by folate deficiency. 

PROPERTIES

CAS Number :
.
Formula :
Molecular Weight :

1492-18-8 (USP)
2060570-47-8 (EP)
C20H31CaN7O12
601.58g/mol

REGULATORY

FDA :
CEP :
.
J DMF :
Indian DFM :
Taiwan DFM :
EU :

005046
1997-051
2013-176
221MF10021
BD-525
(43)0859
DCP or MR or EFSA

Family

  • Reduced folates

Therapeutic area

  • Oncology
  • Detoxifying agents for antineoplastic treatment
  • Vitamin and antianeamic preparations
  • Women’s health
  • Coadjuvant for hormonal contraceptive

Synonims

  • Leucovorin calcium
  • (6RS)-N5-Formyl-5,6,7,8-tetrahydrofolic acid
  • Calcium Leucovorin
  • Folinic Acid Calcium salt
  • L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)