Cerbios has been manufacturing and commercializing HPAPI derivatives of Vitamin D3 since 1993 and is continuously working to develop new products and improve their quality.
Calcitriol is a biologically active metabolite of Vitamin D3. The known sites of action of Calcitriol are: intestine, bone, kidney and parathyroid gland.
It is the most active known form of Vitamin D3 in stimulating intestinal calcium transport and is highly potent (category 4 SafeBridge).
It is also recommended in therapies for the treatment of some autoimmune diseases and certain cancer types (with strict dosage control).
USE
Calcitriol is prescribed for various diseases associated with Vitamin D3 deficiency or related metabolic disorders.
It is used therapeutically for osteoporosis, hyperparathyroidism, renal osteodystrophy, psoriasis, calcium absorption and calcium mobilisation in bone.
Injectable Calcitriol is used in the management of hypocalcaemia in patients undergoing chronic renal dialysis.
CAS Number :
Formula :
Molecular Weight :
32222-06-3
C27H44O3
416.6 g/mol
FDA :
CEP :
Indian DMF :
Korea DMF :
Taiwan DMF :
EU :
CNDMF :
DMF 014718
2002-066,
2012-356
BD-525
20180077170(*)
(43)13210
DCP or MR or EFSA
Y20200001217
(*) Application ongoing
Family
- Vitamin D derivatives
Therapeutic area
- Vitamins and antianaemic preparations
- Dermatologicals
- Bone calcium regulators
Synonims
- 1a,25-dihydroxyvitamin D3
- 1a,25-dihydroxycholecalciferol
- (1a,3b,5Z,7E)-9,10-seco-cholesta-5,7,10(19)-triene-1,3,25-triol
- 9,10-seco(5Z,7E)-5,7,10(19)-cholestatriene-1a,3b,25-triol
- (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1a,3b,25-triol
- (1R,3S)-5-{2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diol
- (1R,3S,5Z)-5-[(2E)-2-{(1R,3aS,7aR)-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyloctahydro-4H-inden-4-yliden}ethyliden]-4-methylidencyclohexan-1,3-diol
